So, by the time Miley Cyrus stops by on September 16, we're sure that Leno will already be on his game for a new segment called "10 at 10." A rep for the show confirmed to MTV News that Miley will participate in the segment, which joins Leno's roster of previously loved bits like "Jay Walking" and "Headlines."

According to the show's rep, "The segment connects Jay with newsmakers and celebs around the world for a series of 10 rapid-fire questions."

On September 14, just a day after he performs at the VMAs, Jay-Z, along with West and Rihanna, will be on the show to perform his single "Run This Town," off his upcoming album Blueprint 3, which is due out on September 11.

In addition to Miley Cyrus and Jay-Z, guests lined up for the show's first week include comedian Robin Williams, actors Tom Cruise and Halle Berry, and musicians Bruce Hornsby and Eric Clapton. According to online chatter, Cruise will be the first guest to try his hand at the "10 at 10" segment when he appears on September 15.

Leno is embarking on a new stage in his career as he transitions from manning "The Tonight Show," now hosted by Conan O'Brien, to a prime-time variety hour.